No, USB 2.0 is way too slow. I have a single 4 drive eSATA array, a G-SPEED eS (without the SATA card), hooked to one of the eSATA ports. The SS4200 eSATA ports support SATA hubs (which is rare for motherboard SATA ports, but I had seen it mentioned in a previous discussion on the SS-4200). I...