Well, I've had a drobo for the better part of a year, and more recently got a droboshare to attach it to. For comparison I also have a ReadyNAS 1100 that I've had for longer.
First up, the drobo is CUTE, and very innovative when it comes to data storage technology. But it ends right at that point. What do I mean?
The array technology is really great. You put drives in, any size, any order, and it just uses them as it needs to. It only sets up parity for actual data, not for the whole disk. If your drobo is relatively empty, you can actually pull out a drive, and then after a little while it will once again become redundant on the remaining disks. No RAID array can do this (and, no, having a hot spare doesn't count. I use all the disk bays in my ReadyNAS and my Drobo - no room for a hot spare)
BUT (Need a bigger font for that BUT), once you get beyond the actual storage, the drobo is VERY limited. First of all, it's USB2. That limits the speed right away. But even worse, it's not even up to the speed limits of USB2. It can't even compete in the same performance arena as another similarly priced RAID array, like the SansDigital MR5CT2.
THEN, there's the droboshare. Yes, the Droboshare turns your drobo into a network-attached disk, but it's PAINFULLY limited. There's only one login and password, and that single login has full read-write access to the drobo - i.e. NO SECURITY. In addition, for some strange reason the droboshare has a gigabit port on it. I'd be overjoyed to see mine even come close to saturating 100megabit, let alone gigabit. There's only smb/cifs access - no ftp, no http, no rsync, no afp, no uPnP (all those other nice things that people on these forums are used to seeing on their ReadyNAS/Qnap/Synology/Thecus/Linksys devices already for years)
So, while the drobo makes a nice, redundant secondary storage, for backups or something like that, it's very light on features when it comes to real day-to-day use. At best, I'd say it would make a good backup for your "real" NAS.