For me, I was getting unbound hit rate from 30%-35% to 65%-75% once I made this change. Remove any upstream server from Cloudflare, quad9, and etcs from Adguad Home. Just include the unbound ipv4 and ipv6. For DoT, I just enabled on unbound end.
127.0.0.1:53535
tcp://127.0.0.1:53535...