Interesting, I will defiantly be looking into the Xbox Optimization toggle. I've not noticed any issues with streaming other than some slow buffering with my Android phone streaming Google Music. However, with the slew of Wifi issues surrounding 4.2 JB I'm hesitant to blame this on my router. Also DLNA streaming over the local LAN has work pretty well for me... Especially since I'm restricted to the shirtty PS3's wireless G as my main client (Until UMS works for the Wii U

) I would assume that the Xbox optimization settings is related to streaming over the internet though....
Hopefully we'll get some more clarification on what exactly the fix is doing from Asus.
All in all my main concern is getting rid of those erratic and very frequent (though short lived) signal dips on the 2.4ghz band.
Please keep us posted if you see the problem return. Also did you do a dirty flash or reset the router after upgrading firmware? Did you change any other settings aside from messing with Enhanced Interference Mitigation?
IT / Computer engineer here too, "Have you restarted your computer yet?" also my usual first question