No disadvantages at all.
I only have an AX88U which is h/w limited to a maximum of 2 concurrent VPN sessions, but for your AXE11000, you might be in luck.
I’m interested in whether it works or not. If so, I will buy an AX11000. Personally, I need to run 4 WireGuard sessions 24x7.
Of course, your choice of VPN Provider will also determine whether you are successful or not. TorGuard seems to support multiple dedicated IPs, and multiple WireGuard tunnels well.
Good luck! Let me know how it goes. I can share some Private WiFI MAC address tricks with you, to take advantage of your tri-band router with multiple WireGuard sessions - although, this seems to be limited to iOS / iPadOS devices.