I picked one up for my father a week ago to consolidate his 7+ USB drives into one storage location. I've loaded in 3x WD Greenpower EARS (Advanced Format) 1.5TB drives, and the setup was fairly straightforward. I used my macbook to configure the device, and it self-updated the firmware a couple of times (each requiring a restart of the device), and then it automatically created a 16TB thin-provisioned volume and shared it. The drobo utility on my mac automatically mounts the drives when I am at home, which is a nice feature for my dad.
In terms of performance, I connected my video editing station (which has a 4x750gb sata RAID10 array with about 100MB/s avg read performance using hdtune) over gigabit to the drobo, and am able to write to the Drobo FS at about 25 MB/s (unscientific) of a single AVI file. In turn, I am able to read the same file at about 25 MB/s (unscientific).
Client machine running Vista Business x64 with a onboard broadcom 1000baseT nic. (Mobo Supermicro X7DVLE dual xeon board) If you guys would like any specific tests done let me know, I have the unit here for another week or two.